Cognitive decline is characterized by neurodegenerative Disease , In the older age groups in the incidence rate is high. In recent years, studies related to AD has made great progress, through epidemiological and pharmacological studies have shown that a lipid-lowering effects of statins (HMGCoA reductase inhibitor) for the potential treatment of AD. AD and the study suggests the relevance of lipid hyperlipidemia is one of the risk factors of AD, therefore, has been Statins are seen as subjects of common cardiovascular drugs, drugs continue to research results in academic sector caused by bursts of sensation.
The American Academy of Neurology published on August 28th “Neurology”, Washington University School of Medicine GailLi, MD, published their latest research topic group: Comparison of lifetime by taking and not taking statins in patients after the death of brain tissue on the difference, come to the “statins help prevent Alzheimer’s disease” conclusion.
Anatomy of the brain Washington University School of mental and behavioral science department GailLi MD, and colleagues of 110 patients aged 65 to 79 years old, voluntarily donate the brain after death for medical research volunteers to do the structure of the brain. The subject of research was called the “thinking of changing (AdultChangesinThought, ACT)”, launched in 1994, are forward-looking cohort study. The study set Health Control group, also aged 65 and above there is no thought disorder in healthy volunteers.
Date, the pathogenesis of Alzheimer’s disease has not yet entirely clear, the basic recognition that the current lesions involved in AD amyloid plaque (plaque) deposition and regional neurofibrillary tangles (tangle), directly to block or disrupt the delivery of key neural pathways brain thinking, leading to memory loss, learning disabilities and speech defects and other symptoms. The focus of AD research has tended to focus on these two aspects. Previous imaging studies have prompted the normal brain, the brain differences in patients with AD. ACT discussion group at the corrected age of death, sex, stroke and other factors, found that taking statins group and those not taking statins group, patients taking the brain protein plaques and neuronal tangles are relatively less.
“Analysis” of research results
Currently on the market statins, including atorvastatin, rosuvastatin, rosuvastatin and simvastatin, etc., are widely used in the treatment of cardiovascular diseases, mainly from the lower low-density lipoprotein cholesterol (LDL -C, commonly known as “bad” cholesterol) level role. As cholesterol has been confirmed in the pathogenesis of Alzheimer’s disease and played an important “negative” role, in recent years scholars have put the treatment on AD drug target fixed on the statin drugs. The head of the subject, Dr. Li said that the direct taking of statins for patients with brain structure of the human body is the first time, this epidemiological investigation or more before the animal is more persuasive. Meanwhile, Li also pointed out that Dr., AD patients were diverse, and perhaps statins can prevent and curb the onset of the disease in some patients. He hoped that one day the medical profession to know what kind of statins for AD treatment may be, and can clearly know the drug is for which type of AD.
Medicine Alzheimer’s Disease – Science in Society Vice WillianThies on the results of the study published opinion, he thought: “AD pathology findings confirmed that AD lesions have been involved in plaque deposits and neuron filament winding, and The data from this area to reveal the anatomy of statins on delaying and preventing the progress of AD is beneficial. “
Our group, another senior researcher Dr. EricLarson explained: “Because of statins on brain anatomy randomized controlled study of effects of some degree of difficulty of the practice, but also related to the ethical and moral issues, the ACT, Epidemiological study design is more coherent than that, and the study was very reliable drug information for patients. “
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